Hits were hard to come by against Orioles starter Brian Matusz and the Red Sox were getting shut out until Varitek hit his fourth homer of the season in the fifth. Lackey gave up ten hits but kept the O’s from any big innings, he went seven innings with three earned runs. Scutaro and Youk both had three-run homers in the seventh to give the Sox a big lead which would almost disappear when the bullpen let Baltimore back in it. Ramon Ramirez gave up a homer and Papelbon gave up a run on three hits before closing the door and holding on for the save.
Red Sox Win 7-6 BOX SCORE
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | R | H | E | |
| Orioles | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 6 | 17 | 0 |
| Red Sox | 0 | 0 | 0 | 0 | 1 | 0 | 6 | 0 | 0 | 7 | 9 | 1 |
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