With Manny Ramirez 90 feet away Kevin Youkilis flew out to right field to end a ninth inning rally losing to the Cardinals 5-4.
Mike Lowell drove home Dustin Pedroia on an RBI single to bring it to 5-4.
Tim Wakefield (4-5) suffered the loss pitching for 7 innings, on seven hits, four runs, three earned, three walks, and four strikeouts.
Goat of the Game: Okie not O.K.
Hideki Okajima gave up a home run to Yadier Molina in the top of of the eighth inning that ended up being the difference as Boston scored with two outs in the bottom of the ninth.
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