Milwaukee Brewers (-165) vs. Pittsburgh Pirates (+152) Probable Pitchers
- Brewers: Brandon Woodruff (2-1, 4.30 ERA)
- Pirates: Mitch Keller (0-3, 6.23 ERA)
San Diego Padres (-166) vs. Cincinnati Reds (+153) Probable Pitchers
- Padres: Joe Musgrove (2-0, 1.89 ERA)
- Reds: Reiver Sanmartin (0-2, 7.11 ERA)
Seattle Mariners (+119) vs. Tampa Bay Rays (-129) Probable Pitchers
- Mariners: Logan Gilbert (2-0, 0.54 ERA)
- Rays: Matt Wisler (1-0, 2.54 ERA)
Colorado Rockies (+147) vs. Philadelphia Phillies (-159) Probable Pitchers
- Rockies: German Marquez (0-0, 4.67 ERA)
- Phillies: Zach Eflin (0-1, 5.27 ERA)
Baltimore Orioles (+237) vs. New York Yankees (-265) Probable Pitchers
- Orioles: Jordan Lyles (1-1, 3.52 ERA)
- Yankees: Luis Severino (1-0, 2.08 ERA)
Miami Marlins (-118) vs. Washington Nationals (+108) Probable Pitchers
- Marlins: Sandy Alcantara (1-0, 1.86 ERA)
- Nationals: Josiah Gray (2-1, 3.14 ERA)
Boston Red Sox (+171) vs. Toronto Blue Jays (-186) Probable Pitchers
- Red Sox: Nick Pivetta (0-3, 10.03 ERA)
- Blue Jays: Kevin Gausman (1-1, 2.89 ERA)
Kansas City Royals (+138) vs. Chicago White Sox (-149) Probable Pitchers
- Royals: Daniel Lynch (1-1, 5.40 ERA)
- White Sox: Dallas Keuchel (1-1, 15.00 ERA)
Chicago Cubs (+144) vs. Atlanta Braves (-156) Probable Pitchers
- Cubs: Marcus Stroman (0-2, 8.78 ERA)
- Braves: Max Fried (1-2, 3.50 ERA)
Detroit Tigers (+122) vs. Minnesota Twins (-132) Probable Pitchers
- Tigers: Eduardo Rodriguez (0-1, 5.27 ERA)
- Twins: Chris Paddack (0-2, 7 K, 5.00 ERA)
New York Mets (-117) vs. St. Louis Cardinals (+107) Probable Pitchers
- Mets: Chris Bassitt (2-1, 3.00 ERA)
- Cardinals: Jordan Hicks–(0-0, 0.00 ERA)
Houston Astros (-109) vs. Texas Rangers (-101) Probable Pitchers
- Astros: Jake Odorizzi (0-2, 9.00 ERA)
- Rangers: Taylor Hearn (0-1, 14 K, 7.59 ERA)
Cleveland Guardians (+147) vs. Los Angeles Angels (-159) Probable Pitchers
- Guardians: Triston McKenzie (0-1, 2.38 ERA)
- Angels: Patrick Sandoval (0-0, 0.00 ERA)
Los Angeles Dodgers (-205) vs. Arizona Diamondbacks (+188) Probable Pitchers
- Dodgers: Tony Gonsolin (1-0, 8 K, 0.69 ERA)
- Diamondbacks: Zach Davies (1-1, 11 K, 5.02 ERA)
Oakland Athletics (+228) vs. San Francisco Giants (-255) Probable Pitchers
- A’s: Daulton Jefferies (1-2, 9 K, 1.17 ERA)
- Giants: Carlos Rodon (2-0, 1.06 ERA)
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